Leukotriene B4 plays a pivotal role in CD40 dependent activation of chronic B lymphocytic leukemia cells Short title: B-CLL and leukotrienes
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چکیده
* Corresponding author: Hans-Erik Claesson MBB, Division of Chemistry II Karolinska Institutet 171 77 Stockholm, Sweden Telephone: +46 8 524 876 27 Fax. +46 8 324 264 E-mail: [email protected] Scientific heading: Neoplasia Total word counts: 3440 Abstract word count: 157 Acknowledgements: This work was supported by grants from Swedish Cancer Society, Funds of Karolinska Institutet, Alfred Österlund ́s Foundation, Royal Physiographic Society and Swedish Medical Research Council. Anquan Liu is supported by the Cancer Research Institute/Concern Foundation, USA. Blood First Edition Paper, prepublished online September 28, 2004; DOI 10.1182/blood-2004-07-2546
منابع مشابه
Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells.
Biosynthesis of leukotrienes (LTs) occurs in human myeloid cells and B lymphocytes. However, the function of leukotrienes in B lymphocytes is unclear. Here, we report that B-cell chronic lymphocytic leukemia (B-CLL) cells produce leukotriene B(4), and that specific leukotriene biosynthesis inhibitors counteracted CD40-dependent activation of B-CLL cells. Studies on the expression of the high-af...
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